open-science

Open source alternative to Claude Science

5.3K stars
Apache-2.0
Active this week
Last commit 2 days ago

Last verified Oct 20, 2026

Run a local-first, model-agnostic AI research workbench with scientific agents, Python/R execution, 24 data connectors, and traceable provenance.

Visit website GitHub5.3K

Read the full breakdownWho it is for, how it works, trade-offs and the FAQ

who it's for

Who open-science is for#

Computational biologists running multi-step pipelines

Open Science's persistent Python and R kernels, built-in bioinformatics connectors (PubMed, genomics databases, structural biology, protein annotation), and 22 scientific skills let a computational biologist run a full pipeline from literature search to data analysis to figure generation inside one workspace. Each artifact retains its provenance so the pipeline is reproducible and auditable.

Skip if:

Your work is purely statistical and already has a well-established Jupyter-based workflow. The desktop app adds overhead you may not need if you are not using agent delegation or the built-in connector features.

Independent researchers without institutional compute

The local-first model means no institutional server or cloud subscription is required to get started. Researchers can run analyses on their own machine and submit long-running jobs to remote HPC clusters via SSH when local resources are insufficient, using the Slurm execution mode added in v0.26.0.

Skip if:

You need a shared, browser-accessible workbench that multiple collaborators use simultaneously from different machines. Open Science is designed for individual researchers working on their own hardware.

AI and ML researchers tracking reproducible experiments

The provenance system, conversation branching, and versioned artifacts make it straightforward to track which model, data, and code path produced a given result. Researchers can explore alternative hypotheses by branching a conversation without losing the original session or blurring the record of earlier results.

Skip if:

Your experiments run entirely in Python scripts or notebooks and you have no need for agent-delegated tasks or scientific database connector integration. A standard notebook environment is simpler in that case.

the problem

The problem it solves#

Scientific research is scattered across tools that do not talk to each other: one chat interface for the AI conversation, a separate Jupyter notebook for code, a local file system for data, database query tools for literature and genomics, and presentation software for reports. At every handoff, context is lost. The agent's reasoning is stored in one window; the code that produced the result is in another; the files are somewhere else.

The deeper problem is verifiability. When an AI agent produces a report or figure, it is rarely obvious which inputs it used, which code path it followed, or whether its claims are supported by the data it queried. Reproducibility collapses if you cannot trace a result back to its evidence.

how open-science solves it

How it solves it#

Model-agnostic provider support

Connect any cloud provider via API or an OpenAI-compatible gateway: OpenAI, Anthropic, xAI, and DeepSeek are built-in alongside dozens of additional providers. You select the model and reasoning effort per session, and switching providers does not change the workbench or project files.

Persistent Python and R execution

Open Science provides persistent Python and R kernels alongside stateless shell execution. Variables and analytical state survive across related steps within a session, and a Variables view lets researchers inspect the live namespace between executions. Remote SSH compute handles jobs that exceed local resources.

24 built-in scientific data connectors

Connectors cover scientific literature, PubMed, bioRxiv, genomics databases, BioMart, structural biology, protein annotation, ChEMBL, ZINC, clinical trials data, and more. Each connector runs through the workspace permission system, with per-tool Allow, Ask, or Block controls.

Traceable research artifacts with provenance

Every generated report, figure, table, or notebook is stored as a versioned, checksummed artifact. Its Provenance view records the producer code, execution history, environment details, the conversation branch, and reviewer findings. Missing evidence is shown as unavailable rather than guessed.

22 featured scientific skills

Purpose-built skills for AlphaFold2, Boltz, ESMFold2, Chai-1, LigandMPNN, literature review, computational biology, and remote HPC compute ship with the app. Researchers can also import personal or community-shared skills using the Skills system, or preview and install skills from GitHub.

Conversation branching without lost work

Edit a completed user message to resend a revised prompt from that point. Open Science creates a new message branch instead of deleting the turns that followed, and revision controls let you switch between the original and alternative paths. Provenance stays tied to the exact branch that produced each artifact.

strengths · trade-offs

Strengths and trade-offs#

Strengths

Apache-2.0 with no seat licenseThe app is free to download and run. You pay only for the model API or compute you choose to use. Unlike Claude Science and other commercial research platforms, there is no per-user charge or subscription required to run the workbench itself. The source code is inspectable and forkable.
Local-first data ownershipProject files, sessions, notebooks, and generated artifacts are stored on your computer. External calls go only through services you explicitly configure. No research data is transmitted to AIPOCH infrastructure, which matters for institutions with data governance requirements.
#1 on BiomniBench-DA Public 50Open Science achieved the highest ranking score in the BiomniBench-DA Public 50 comparison, scoring 79.05 with gpt-5.6-sol at xhigh effort. The result averages a Gemini 3.1 Pro judge score of 81.04 and a DeepSeek v4-pro judge score of 77.06, placing it first among the collected Public 50 results.
Cross-platform desktop with guided setupShips as a native desktop app for macOS (Apple Silicon and Intel), Windows, and Linux. No Docker, no database, no server configuration is needed for local use. The first-run wizard handles environment checks, model provider validation, and notebook runtime setup automatically.

Trade-offs

-Young project with 47 open issuesOpen Science was created in July 2026 and had 47 open GitHub issues as of the research date. The tool is in active development, and some workflows or edge cases may be incomplete or subject to change between releases. Review the release notes before upgrading in a production research context.
-Inference cost is not includedThe workbench is free, but every agent session calls an external model API at your cost. High-volume or long-running research tasks can generate significant API charges depending on the model and provider you choose. Budget planning around model usage is necessary for sustained research work.
-Desktop-only, no shared web interfaceOpen Science runs as an Electron desktop application on individual machines. Teams that need a shared, browser-accessible research environment where multiple collaborators work in the same session simultaneously will need a different approach, as there is no server mode or multi-user web UI.

versus alternatives

open-science vs alternatives#

Open Science vs Claude Science

Open Science and Claude Science both target scientists who want AI assistance across research workflows. The key difference is control: Open Science is an open-source, model-agnostic desktop app; Claude Science is Anthropic's proprietary cloud-native research product.

Feature	Open Science	Claude Science
License	Apache-2.0	Proprietary
Hosting	Local desktop app	Cloud-only
Model choice	Any provider via API or compatible gateway	Anthropic Claude models
Pricing	Free workbench; pay for model API	Proprietary pricing
Scientific connectors	24 built-in	Not publicly documented
Platform	macOS, Windows, Linux	Web / cloud
Source code	Public (GitHub)	Closed

Open Science is the stronger choice when your research requires data to stay on your machine, when you want to run different model providers for different tasks, or when institutional policy prohibits sending data to cloud platforms. The Apache-2.0 license means you can inspect and fork the workbench code, and the 24 built-in scientific connectors plus 22 skills cover most computational biology and data science workflows without additional configuration.

Claude Science is worth considering if you need Anthropic's specific model capabilities with no local setup, no model configuration, and no API key management. As a proprietary first-party product, it may offer tighter model integration than Open Science's provider-agnostic approach. Teams that are already in the Anthropic ecosystem and comfortable with cloud-only data handling will have less friction getting started.

tech stack · detected from GitHub

What it's built on#

Languages: JavaScriptTypeScript
Frameworks: React
Tooling: esbuild

frequently asked

FAQ#

Is Open Science free to use?

Yes. Open Science is Apache-2.0 licensed and free to download and run on your own machine. You pay only for the model API or external compute you connect to it. AIPOCH does not charge a seat license or subscription for the workbench itself.

Which AI models does Open Science support?

Open Science is model-agnostic. Built-in providers include OpenAI, Anthropic, xAI, DeepSeek, Zhipu AI, Kimi, MiniMax, StepFun, NVIDIA, and others, plus any OpenAI-compatible custom gateway or self-hosted endpoint. The available model catalog follows your provider account and is selected per session.

Is Open Science an alternative to Claude Science?

Yes. Open Science is an Apache-2.0 alternative to Claude Science and similar proprietary AI research tools. Unlike Claude Science, it is not tied to a single model provider, runs locally on your machine without sending data to a third-party platform, and carries no per-seat charge. The project's own documentation notes it is not affiliated with or endorsed by Anthropic.

How does Open Science handle data privacy?

Open Science is local-first: project files, sessions, notebooks, and artifacts are stored on your computer. External calls go only through model providers and data connectors you explicitly configure. The app does not send research data to AIPOCH servers. This makes it suitable for institutions with data governance or confidentiality requirements.

What scientific databases can Open Science query?

Open Science includes 24 built-in connectors covering scientific literature, PubMed, bioRxiv, genes and ontologies, genomics databases, BioMart, genetic variants, structural biology, ChEMBL, ZINC, clinical trials, drug regulatory data, cancer model databases, and research resources. Connector access is controlled by per-tool permission settings (Always allow, Ask each time, or Block).

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Open Science vs Claude Science

Feature	Open Science	Claude Science
License	Apache-2.0	Proprietary
Hosting	Local desktop app	Cloud-only
Model choice	Any provider via API or compatible gateway	Anthropic Claude models
Pricing	Free workbench; pay for model API	Proprietary pricing
Scientific connectors	24 built-in	Not publicly documented
Platform	macOS, Windows, Linux	Web / cloud
Source code	Public (GitHub)	Closed

Who open-science is for#

Computational biologists running multi-step pipelines

Skip if:

Independent researchers without institutional compute

Skip if:

AI and ML researchers tracking reproducible experiments

Skip if:

The problem it solves#

How it solves it#

Model-agnostic provider support

Persistent Python and R execution

24 built-in scientific data connectors

Traceable research artifacts with provenance

22 featured scientific skills

Conversation branching without lost work

Strengths and trade-offs#

Strengths

Trade-offs

open-science vs alternatives#

Open Science vs Claude Science

What it's built on#

FAQ#

Similar open-source tools#

Open source tools in these categories#

AI & Machine Learning

Product & Project Management

Data & Analytics

Find open source alternatives to paid software

Who open-science is for#

Computational biologists running multi-step pipelines

Skip if:

Independent researchers without institutional compute

Skip if:

AI and ML researchers tracking reproducible experiments

Skip if:

The problem it solves#

How it solves it#

Model-agnostic provider support

Persistent Python and R execution

24 built-in scientific data connectors

Traceable research artifacts with provenance

22 featured scientific skills

Conversation branching without lost work

Strengths and trade-offs#

Strengths

Trade-offs

open-science vs alternatives#

Open Science vs Claude Science

What it's built on#

FAQ#

Similar open-source tools#

Open source tools in these categories#

AI & Machine Learning

Product & Project Management

Data & Analytics

Find open source alternatives to paid software